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Selected Publications


Misra, K., Luo, H., Li, S., Matise, M., and Xiang, M. (2014) Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFbeta signaling to specify V2b interneurons in the spinal cord. Development 141:187-198 . (PDF reprint)

Islam, M.M., Li, Y., Luo, H., Xiang, M., and Cai, L. (2013) Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation. Biol. Open 2:1125-1136 . (PDF reprint)

Xiang, M. (2013) Xiang, M. and Li, S. (2013) Foxn4: a multi-faceted transcriptional regulator of cell fates in vertebrate development. Sci. China Life Sci. 56:985-993 . (PDF reprint)

Wu, F., Li, R., Umino, Y., Kaczynski, T.J., Sapkota, D., Li, S., Xiang, M., Fliesler, S.J., Sherry, D.M., Gannon, M., Solessio, E., and Mu, X. (2013) Onecut1 is essential for horizontal cell genesis and retinal integrity. J. Neurosci. 33:13053-13065 . (PDF reprint)

Xiang, M. (2013) Intrinsic control of mammalian retinogenesis. Cell. Mol. Life Sci. 70:2519-2532 . (PDF reprint)

Jin, K. and Xiang, M. (2012) In vitro explant culture and related protocols for the study of mouse retinal development. Methods Mol. Biol. 884:155-165 . (PDF reprint)

Zou, M., Li, S., Klein, W. H., and Xiang, M. (2012) Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev. Biol. 364:114-127 . (PDF reprint)

Luo, H., Jin, K., Xie, Z., Qiu, F., Li, S., Zou, M., Cai, L., Hozumi, K., Shima, D. T., and Xiang, M. (2012) Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors. Proc. Natl. Acad. Sci. USA 109:E553-E562 . (PDF reprint)

Ding, Q., Joshi. P. S., Xie, Z.-H., Xiang, M., and Gan, L. (2012) BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord. Proc. Natl. Acad. Sci. USA 109:1566-1571 . (PDF reprint)

Xiang, M., Jiang, H., Jin, K., and Qiu, F. (2011) Molecular control of retinal ganglion cell specification and differentiation. In Glaucoma - Basic and Clinical Concepts (R. Shimon, ed.), pp. 65-84, InTech, Rijeka. (PDF reprint)

Poschl, J., Lorenz, A., von Bueren, A.O., Peraud, A., Li, S., Tonn, J.-C., Herms, J., Xiang, M., Rutkowski, S., Kretzschmar, H.A., and Schuller, U. (2011) Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans. Oncogene 30:4721-4730 . (PDF reprint)

Jin, K. and Xiang, M. (2011) Ebf1 deficiency causes increase of Muller cells in the retina and abnormal topographic projection at the optic chiasm. Biochem. Biophys. Res. Commun. 414:539-544 . (PDF reprint)

Li, S. and Xiang, M. (2011) Kunzevitzky, N. J., Almeida, M. V., Duan, Y., Li, S., Xiang, M., and Goldberg, J. L. (2011) Foxn4 is required for retinal ganglion cell distal axon patterning. Mol. Cell. Neurosci. 46:731-741 . (PDF reprint)

Li, S. and Xiang, M. (2011) Foxn4 influences alveologenesis during lung development. Dev. Dyn. 240:1512-1517. Dev. Dyn. 240:1512-1517 . (PDF reprint)

Li, S., Misra, K., and Xiang, M. (2010) A Cre transgenic line for studying V2 neuronal lineages and functions in the spinal cord. Genesis 48:667-672 . (PDF reprint)

Panayi, H., Orford, M., Panayiotou, E., Genethliou, N., Mean, R., Lapathitis, G., Li, S., Xiang, M., Kessaris, N., Richardson, W., and Malas, S. (2010) SOX1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord. J. Neurosci. 30:12274-12280 . (PDF reprint)

Jin, K., Jiang, H., Mo, Z., and Xiang, M. (2010) Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J. Neurosci. 30:11902-11916 . (PDF reprint)

Jiang, H. and Xiang, M. (2009) Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1. J. Neurosci. 29:10449-10459 . (PDF reprint)

Ichikawa, H., Terayama, R., Yamaai, T., Jacobowitz, D. M., Qiu, F., Xiang, M., and Sugimoto, T. (2009) Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development. Cell. Mol. Neurobiol. 29:691-698 . (PDF reprint)

Huang, M., Sage, C., Li, H., Xiang, M., Heller, S., and Chen, Z. -Y. (2008) Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development. Dev. Dyn. 237:3305-3312 . (PDF reprint)

Qiu, F., Jiang, H., and Xiang, M. (2008) A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J. Neurosci. 29:10449-10459 . (PDF reprint)

Chellappa, R., Li, S., Pauley, S., Jahan, I., Jin, K., and Xiang, M. (2008) Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system. Mol. Cell. Biol. 28:1905-1914 . (PDF reprint)

Collin, R. W. J., Chellappa, R., Pauw, R. -J., Vriend, G., Oostrik, J., van Drunen, W., Huygen, P. L., Admiraal, R., Hoefsloot, L. H., Cremers, F. P. M., Xiang, M., Cremers, C. W. R. J., and Kremer, H. (2008) Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding. Hum. Mutat. 29:545-554 . (PDF reprint)

Del Barrio, M. G., Taveira-Marques, R., Muroyama, Y., Yuk, D.-I., Li, S., Wines-Samuelson, M., Shen, J., Smith, H. K., Xiang, M., Rowitch, D., and Richardson, W. D. (2007) A regulatory network involving Foxn4, Mash-1 and Delta-like 4/Notch-1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development 134:3427-3436 . (PDF reprint)

Fujitani, Y., Fujitani, S., Luo, H., Qiu, F., Burlison, J., Long, Q., Kawaguchi, Y., Edlund, H., MacDonald, R. J., Furukawa, T., Fujikado, T., Magnuson, M. A., Xiang, M., and Wright, C. V. E. (2006) Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development 133:4439-4450 . (PDF reprint)

Li, S. and Xiang, M. (2006) Barhl1 is required for maintenance of a large population of neurons in the zonal layer of the superior colliculus. Dev. Dyn. 235:2260-2265 . (PDF reprint)

Xiang, M. (2006) Intrinsic mechanisms that control the specification of mammalian retinal cell types. In Trends in Neurosciences (X.M. Wang, M. Zhuo, X.J. Li, J. Chen, T.M. Gao, M. Fan, & L. Xu, eds.), Vol. 4, pp. 80-94, Higher Education Press, Beijing. (PDF reprint)

Fritzsch, B., Pauley, S., Matei, V., Katz, D. M., Xiang, M. and Tessarollo, L. (2005) Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain. Hear Res. 206:52-63 . (PDF reprint)

Ichikawa, H., Qiu, F., Xiang, M. and Sugimoto, T. (2005) Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus. Brain Res. 1053:203-206 . (PDF reprint)

Li, S., Misra, K., Matise, M. and Xiang, M. (2005) Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc. Natl. Acad. Sci. USA 102:10688-10693. (PDF reprint)

Yu, C., Dong, M., Wu, X., Li, S., Huang, S., Su, J., Wei, J., Shen, Y., Mou, C., Xie, X., Lin, J., Yuan, S., Yu, X., Yu, Y., Du, J., Zhang, S., Peng, X., Xiang, M. and Xu, A. (2005) Genes "waiting" for recruitment by the adaptive immune system: the insights from Amphioxus. J. Immunol. 174:3493-3500. (PDF reprint)

Ichikawa, H., Mo, Z., Xiang, M. and Sugimoto, T. (2005) Brn-3a deficiency increases tyrosine hydroxylase-immunoreactive neurons in the dorsal root ganglion. Brain Res. 1036:192-195. (PDF reprint)

Ichikawa, H., Schulz S., Hollt, V., Mo, Z., Xiang, M. and Sugimoto, T. (2005) Effect of Brn-3a deficiency on primary nociceptors in the trigeminal ganglion. Neurosci. Res. 51:445-451. (PDF reprint)

Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M. and Xiang, M. (2004) Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43:795-807. (PDF reprint)

Ichikawa, H., Mo, Z., Xiang, M. and Sugimoto, T. (2004) Effect of Brn-3a deficiency on parvalbumin-immunoreactive primary sensory neurons in the dorsal root ganglion. Dev. Brain Res. 150:41-45. (PDF reprint)

Li, S., Qiu, F., Xu, A., Price, S. M., and Xiang, M. (2004) Barhl1 regulates migration and survival of cerebellar granule cells by controlling expression of the neurotrophin-3 gene. J. Neurosci. 24:3104-3114. (PDF reprint)

Mo, Z., Li, S., Yang, X., and Xiang, M. (2004) Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells. Development 131:1607-1618. (PDF reprint)

Weiss S., Gottfried, I., Mayrose, I., Khare, S. L., Xiang, M., Dawson, S. J., and Avraham, K. B. (2003) The DFNA15 deafness mutation affects POU4F3 protein stability, localization and transcriptional activity. Mol. Cell. Biol. 23:7957-7964. (PDF reprint)

Xiang, M., Maklad, A., Pirvola, U. and Fritzsch, B. (2003) Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation. BMC Neurosci. 4:2. (PDF reprint)

Ichikawa, H., Mo, Z., Xiang, M., and Sugimoto, T. (2002) Effect of Brn-3a deficiency on nociceptors and low-threshold mechanoreceptors in the trigeminal ganglion. Mol. Brain Res. 104:240-245. (PDF reprint)

Ichikawa, H., Yamaai, T., Jacobowitz, D. M., Mo, Z., Xiang, M., and Sugimoto, T. (2002) Effect of Brn-3a deficiency on parvalbumin-, calbindin D-28k-, calretinin- and calcitonin gene-related peptide-immunoreactive primary sensory neurons in the trigeminal ganglion. Neuroscience 113:537-546. (PDF reprint)

Li, S., Price, S. M., Cahill, H., Ryugo, D. K., Shen, M. M., and Xiang, M. (2002) Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 129:3523-3532. (PDF reprint)

Ichikawa, H., Yamaai, T., Mo, Z., Xiang, M., and Sugimoto, T. (2002) Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. Neuroreport 13:409-412. (PDF reprint)

Huang, E. J., Liu, W., Fritzsch, B., Bianchi, L. M., Reichardt, L. F., and Xiang, M. (2001) Brn3a is a transcriptional regulator of soma size, target field innervation, and axon pathfinding of inner ear sensory neurons. Development 128:2421-2432. (PDF reprint)

Liu, W., Mo, Z., and Xiang, M. (2001) The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development. Proc. Natl. Acad. Sci. USA 98:1649-1654. (PDF reprint)

Liu, W., Khare, S. L., Liang, X., Peters, M. A., Liu, X., Cepko, C. L., and Xiang, M. (2000) All Brn3 genes can promote retinal ganglion cell differentiation in the chick. Development 127:3237-3247. (PDF reprint)

Liu, W., Wang, J.-H., and Xiang, M. (2000) Specific expression of the LIM/homeodomain protein Lim-1 in horizontal cells during retinogenesis. Dev. Dyn. 217:320-325. (PDF reprint)

Huang, E. J., Zang, K., Schmidt, A., Saulys, A., Xiang, M., and Reichardt, L. F. (1999) POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development 126:2869-2882. (PDF reprint)

Xiang, M., Gao, W.-Q., Hasson, T., and Shin, J. J. (1998) Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development 125, 3935-3946. (PDF reprint)

Xiang, M. (1998) Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev. Biol. 197:155-169. (PDF reprint)

Xiang, M., Gan, L., Li, D., Zhou, L., Chen, Z.-Y., Wagner, D., O'Malley, B. W., Jr., Klein, W. H., and Nathans, J. (1997) Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb. Symp. Quant. Biol. LXII:325-336.

Xiang, M., Gan, L., Li, D., Chen, Z.-Y., Zhou, L., O'Malley, B. W., Klein, W. H., and Nathans, J. (1997) Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc. Natl. Acad. Sci. USA 94:9445-9450. (PDF reprint)

Xiang, M., Gan, L., Zhou, L., Klein, W. H., and Nathans, J. (1996) Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc. Natl. Acad. Sci. USA. 93:11950-11955. (PDF reprint)

Gan, L., Xiang, M., Zhou, L., Wagner, D., Klein, W. H., and Nathans, J. (1996) POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. USA. 93:3920-3925. (PDF reprint)

Xiang, M., Zhou, L., Macke, J. P., Yoshioka, T., Hendry, S. H. C., Eddy, R. L., Shows, T. B., and Nathans, J. (1995) The Brn-3 family of POU-domain factors: primary structure, binding specificity and expression in subsets of retinal ganglion cells and somatosensory neurons. J. Neurosci. 15:4762-4785. (PDF reprint)

Xiang, M., Zhou, L., Peng, Y.-W., Eddy, R. L., Shows, T. B., and Nathans, J. (1993) Brn-3b: a POU-domain gene expressed in a subset of retinal ganglion cells. Neuron 11:689-701.